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Silver/eye abnormalities (MCOA)

Summary

Silver coat colours include the eye-catching black silver (aka silver dapple) and bay silver.

The silver gene alters the distribution of black pigment but does not affect red. This means that the effect of the silver gene is not visible on chestnut horses and other colours that have no black, such as palomino.

In addition to its effect on colour the silver gene is thought to cause eye abnormalities in some silver horses (not all). These are referred to as multiple congenital ocular abnormalities (MCOA). These abnormalities can affect vision. Horses with two copies of the silver gene are substantially more likely to show signs of MCOA than those with one copy of the gene.

Gene or region and technical reference

Gene: PMEL (causative). Reference: Brunberg et al., 2006

Reported alleles

n. Test developed using animal controls.

Z. Test developed using animal cases.


horse

This handsome silver stallion is Gillean of Liosmor aka Silver. He is a Highland Pony. Thank-you to Rosemarkie Highland Ponies for sharing this beautiful picture.

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There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Pedigree

$33 DNA profile ... more


Good looks


Coat colour

$9 Agouti (bay factor) ... more

$9 Red/black ... more


Coat pattern

$9 Frame overo/lethal white syndrome (OLWS) ... more

$9 Grey/melanoma ... more

$9 Lp/Appaloosa/night blindness (CSNB) ... more

$9 PATN1 coat pattern modifier (PATN1) ... more

$9 Roan marker ... more

$9 Sabino 1 ... more

$9 Splashed white 1/deafness (SW1) ... more

$9 Splashed white 2/deafness (SW2) ... more

$9 Splashed white 3/deafness (SW3) ... more

$9 Tobiano ... more

$9 W13 dominant white (W13) ... more

$9 W20 white markings (W20) ... more

$9 W22 dominant white (W22) ... more

$9 W25 dominant white (W25) ... more

$9 W26 dominant white (W26) ... more

$9 W27 dominant white (W27) ... more


Colour dilution

$9 Champagne ... more

$9 Cream ... more

$9 Dun and d1 (nd1) ... more

$9 Pearl ... more

$9 Silver/eye abnormalities (MCOA)

Good health


Paint horses

$9 Splashed white 2/deafness (SW2) ... more

$9 Splashed white 3/deafness (SW3) ... more


Pure- and part-bred Akhal-Tekes

$14 Naked foal syndrome (NFS) ... more


Good health


Multiple breeds

$14 Foal immunodeficiency syndrome (FIS) ... more

$14 Fragile foal syndrome (FFS) ... more

$9 Frame overo/lethal white syndrome (OLWS) ... more

$9 Grey/melanoma ... more

$9 Lp/Appaloosa/night blindness (CSNB) ... more

$14 Polysaccharide storage myopathy 1 (PSSM1) ... more

$9 Silver/eye abnormalities (MCOA)

$9 Splashed white 1/deafness (SW1) ... more


Pure- and part-bred Arabians

$14 Cerebellar abiotrophy (CA) ... more

$14 Lavender foal syndrome (LFS) ... more

$14 Occipitoatlantoaxial malformation (OAAM) ... more

$14 Severe combined immune deficiency (SCID) ... more


Pure- and part-bred Connemaras

$14 Hoof wall separation disease (HWSD) ... more


Pure- and part-bred Friesians

$14 Friesian dwarfism ... more

$14 Hydrocephalus ... more


Pure- and part-bred Miniature horses

$14 D1 form of Miniature dwarfism (D1) ... more

$14 D2 form of Miniature dwarfism (D2) ... more

$14 D3 form of Miniature dwarfism (D3) ... more

$14 D4 form of Miniature dwarfism (D4) ... more

$140 Skeletal atavism (SA) ... more


Pure- and part-bred Quarter Horses and Paints

$14 Glycogen branching enzyme deficiency (GBED) ... more

$14 Hereditary equine regional dermal asthenia (HERDA) ... more

$14 Hyperkalaemic periodic paralysis (HYPP) ... more

$14 Malignant hyperthermia (MH) ... more


Pure- and part-bred Saddlebreds

$14 Junctional epidermolysis bullosa (JEB2) ... more


Good moves


Gaited horses

$9 Lateral gait marker ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.