Foal immunodeficiency syndrome (FIS)
Foal Immunodeficiency Syndrome (FIS) is a fatal inherited disorder that has been found in pure and part-bred Fell Ponies, Dale Ponies and Gypsy breeds. Foals with FIS are normal at birth, but within a few weeks develop severe anaemia and B-lymphopenia. If they are not euthenased they will die from the effects of opportunistic infections.
FIS is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female horses, while "recessive" means that a horse needs to inherit the FIS mutation from both its sire and its dam to be affected.
Gene or region and technical reference
Gene: SLC5A3 (causative). Reference: Fox-Clipsham et al. (2011)
n. Test developed using manufactured DNA, animal controls.
FIS. Test developed using manufactured DNA.