Glycogen branching enzyme deficiency (GBED)
Summary
Glycogen branching enzyme deficiency (GBED) is one of the 5 tests in the 5-panel. The 5-panel is relevant to Quarter Horses, Paints, Appaloosas, Quarter Ponies and any other breeds with some Quarter Horse bloodlines.
Glycogen branching enzyme deficiency (GBED) is a genetic disorder found in pure and part-bred Quarter Horses and Paint horses. GBED usually causes abortions. Foals that survive until birth show severe weakness, seizures, and low body temperature. GBED is always fatal.
GBED can happen in both male and female foals. Foals with GBED need to have gotten the GBED mutation from both parents, not just one. When a horse is passed the GBED mutation from just one parent it is called a GBED carrier.
All known cases have occurred in descendents of Zantanon, a QH stallion born in 1917.
Gene or region and technical reference
Gene: GBE1 (causative). Reference: Ward et al. (2004)
Reported alleles
n. Test developed using manufactured DNA, animal controls.
GBED. Test developed using manufactured DNA, animal cases.
Panels: groups of tests that are often ordered together
This test is in the QH health panel.
This test is in the QH health & colour panel.
