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Hyperkalaemic periodic paralysis (HYPP)

Summary

HYPP is one of the 5 tests in the 5-panel. The 5-panel is relevant to Quarter Horses, Paints, Appaloosas, Quarter Ponies and any other breeds with some Quarter Horse bloodlines. HYPP is only found in the descendants of Impressive, an American Quarter Horse born in 1969. Impressive was a halter horse World Champion that produced a large number of World Champion offspring.

The most common signs of HYPP are muscle twitching and spasm occurring intermittently and starting at 2-3 years of age. Severe cases can have muscle weakness, with the worst instances causing collapse or death. HYPP carriers are also reported to have a marked increase in musculature.

The HYPP test is only relevant to horses with Impressive in their pedigree. Just remember if you’re checking your horse’s pedigree to go back far enough to reach 1969 or earlier. HYPP is extremely rare here in Australia.

Gene or region and technical reference

Gene: SCN4A (causative). Reference: Rudolph et al. (1992)

Reported alleles

n. Test developed using manufactured DNA, animal controls.

HYPP. Test developed using manufactured DNA.

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There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

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Multiple breeds

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$9 Silver/eye abnormalities (MCOA) ... more

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Pure- and part-bred Arabians

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Pure- and part-bred Quarter Horses and Paints

$14 Glycogen branching enzyme deficiency (GBED) ... more

$14 Hereditary equine regional dermal asthenia (HERDA) ... more

$14 Hyperkalaemic periodic paralysis (HYPP)

$14 Malignant hyperthermia (MH) ... more


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Gaited horses

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Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.