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Junctional epidermolysis bullosa (JEB2)

Summary

Junctional epidermolysis bullosa (JEB) causes a failure in the skin's normal attachment to the body. Affected foals are usually born alive, but will develop sores and skin tears extremely easily. There is currently no effective treatment for JEB.

JEB is an autosomal recessive disorder. Autosomal disorders are equally likely to affect male or female horses, while "recessive" means that a horse needs to inherit the JEB mutation from both its sire and its dam to be affected. Horses that have inherited the JEB mutation from just one parent are called JEB carriers, and do not have physical signs of this disorder.

The Saddlebred form of JEB has been detected in Saddlebreds and Racking Horses. It may also be present in other related breeds, and part-bred horses with some Saddlebred blood.

This test is not useful for detecting JEB in heavy horses.

Gene or region and technical reference

Gene: LAMA3 (causative). Reference: Graves, Henney and Ennis. (2009)

Reported alleles

n. Test developed using manufactured DNA, animal controls.

JEB. Test developed using manufactured DNA, animal cases.

Order tests

There is a one-off sample processing fee of $40 per animal plus the cost of your tests.

How many animals are you testing? Discount or society code:


Pedigree

$33 DNA profile ... more


Good looks


Coat colour

$9 Agouti (bay factor) ... more

$9 Red/black ... more


Coat pattern

$9 Frame overo/lethal white syndrome (OLWS) ... more

$9 Grey/melanoma ... more

$9 Lp/Appaloosa/night blindness (CSNB) ... more

$9 PATN1 coat pattern modifier (PATN1) ... more

$9 Roan marker ... more

$9 Sabino 1 ... more

$9 Splashed white 1/deafness (SW1) ... more

$9 Splashed white 2/deafness (SW2) ... more

$9 Splashed white 3/deafness (SW3) ... more

$9 Tobiano ... more

$9 W13 dominant white (W13) ... more

$9 W20 white markings (W20) ... more

$9 W22 dominant white (W22) ... more

$9 W25 dominant white (W25) ... more

$9 W26 dominant white (W26) ... more

$9 W27 dominant white (W27) ... more


Colour dilution

$9 Champagne ... more

$9 Cream ... more

$9 Dun and d1 (nd1) ... more

$9 Pearl ... more

$9 Silver/eye abnormalities (MCOA) ... more


Good health


Paint horses

$9 Splashed white 2/deafness (SW2) ... more

$9 Splashed white 3/deafness (SW3) ... more


Pure- and part-bred Akhal-Tekes

$14 Naked foal syndrome (NFS) ... more


Good health


Multiple breeds

$14 Foal immunodeficiency syndrome (FIS) ... more

$14 Fragile foal syndrome (FFS) ... more

$9 Frame overo/lethal white syndrome (OLWS) ... more

$9 Grey/melanoma ... more

$9 Lp/Appaloosa/night blindness (CSNB) ... more

$14 Polysaccharide storage myopathy 1 (PSSM1) ... more

$9 Silver/eye abnormalities (MCOA) ... more

$9 Splashed white 1/deafness (SW1) ... more


Pure- and part-bred Arabians

$14 Cerebellar abiotrophy (CA) ... more

$14 Lavender foal syndrome (LFS) ... more

$14 Occipitoatlantoaxial malformation (OAAM) ... more

$14 Severe combined immune deficiency (SCID) ... more


Pure- and part-bred Connemaras

$14 Hoof wall separation disease (HWSD) ... more


Pure- and part-bred Friesians

$14 Friesian dwarfism ... more

$14 Hydrocephalus ... more


Pure- and part-bred Miniature horses

$14 D1 form of Miniature dwarfism (D1) ... more

$14 D2 form of Miniature dwarfism (D2) ... more

$14 D3 form of Miniature dwarfism (D3) ... more

$14 D4 form of Miniature dwarfism (D4) ... more

$140 Skeletal atavism (SA) ... more


Pure- and part-bred Quarter Horses and Paints

$14 Glycogen branching enzyme deficiency (GBED) ... more

$14 Hereditary equine regional dermal asthenia (HERDA) ... more

$14 Hyperkalaemic periodic paralysis (HYPP) ... more

$14 Malignant hyperthermia (MH) ... more


Pure- and part-bred Saddlebreds

$14 Junctional epidermolysis bullosa (JEB2)

Good moves


Gaited horses

$9 Lateral gait marker ... more

Tests can be in the list more than once when the gene in question has more than one effect. It is OK to select the same test once or more than once, the price is the same.